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ESM Technologies: 2014 HCS

2213 Missouri Ave.
Carthage, MO
Phone: (417) 458-4822
E-mail: chaynes@esmingredients.com
Website: www.esmingredients.com

NEM: Backed by Science

NEM brand eggshell membrane is a unique, multi-patented, U. S.-domestic food-sourced ingredient backed by multiple published studies highlighting its exceptional safety and benefits to joints and the surrounding soft tissue. NEM is derived from the thin inner membranes of chicken eggshells. It is primarily composed of fibrous proteins including collagen types I, V and X, as well as other sulfurrich proteins. It also contains glucosamine and glycosaminoglycans, such as chondroitin sulfate and hyaluronic acid, as well as other components associated with healthy joint tissue.

The efficacy of NEM is supported by two open-label pilot clinical studies and one multicenter, randomized, doubleblind, placebo-controlled human clinical trial demonstrating that a once-daily 500 mg dose of NEM significantly improves joint comfort and flexibility in individuals with general joint discomfort and knee osteoarthritis.1,2 In the openlabel studies, evaluations were made after seven days and again after 30 days, with significance noted at both time periods. In the RCT study, the evaluations occurred at 10, 30 and 60 days with significance at the 10-day time period and continuation of the positive trend throughout the 60-day study period. Displaying the fast and continued results were the numbers: >50 percent of subjects noted >20 percent reduction in pain at 10 days with continued improvement of nearly 70 percent of subjects with >20 percent reduction in pain after 60 days; similarly nearly onethird of subjects noted >50 percent reduction in pain at 10 days with continued improvement of >30 percent subjects noting >50 percent reduction in pain at 60 days. No evaluations were made in either study at earlier time periods, so it is possible that the beneficial effects might have had statistical significance sooner in the treatment period.

Furthermore, an independent, multicenter, open-label clinical trial conducted in Germany was published earlier this year which reaffirmed the findings from the U.S. studies.3 This study demonstrated that one 500 mg dose/day of NEM significantly reduced pain in individuals with moderate knee or hip osteoarthritis, both rapidly and continuously. As in the other trials, there were no notable side effects.

Augmenting the results of these efficacy studies are two studies detailing one potential mechanism of action for NEM’s benefits. The first was an in-vitro human cell culture study.4 This study provided preliminary evidence that NEM exerts an immunomodulatory effect that inhibits the uncontrolled release of specific pro-inflammatory cytokines such as TNF-a.

These findings were then supported by results from an animal study. The goal of the animal study was to evaluate the effects of NEM on pro-inflammatory and anti-inflammatory cytokines following oral administration in both healthy and inflammation induced rats.5 The results of this study revealed that oral supplementation with NEM can influence both early-phase proinflammatory cytokines like IL- 1ß and TNF-a as well as laterphase proinflammatory cytokines like MCP-1, MIP-1a and ß, RANTES and VEGF. There was also a mild effect on the anti-inflammatory cytokine IL-10 consistent with restoring immune homeostasis.

NEM has also been researched for its efficacy in animals. In an independent crossover study, supplementation with NEM for five weeks improved flexion in cranes with chronic tarsal issues (similar to the ankle joint in humans).6 A second independent study was conducted to evaluate an NEM-containing equine joint health supplement in camels.7 This study found that supplementation with NEM for six weeks showed a positive effect on PIIANP, a biomarker of cartilage formation.

As you can see, NEM brand eggshell membrane has been fully evaluated for safety and joint related efficacy in multiple formats. And the research won’t stop here—ESM Technologies is continuing to study the effects, nutrients, delivery formats and uses.


1 Ruff KJ, DeVore DP, Leu MD, and Robinson MA: Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open label human clinical studies. Clinical Interventions in Aging (2009) 4: 235-240.

2 Ruff KJ, Winkler A, Jackson RW, DeVore DP, and Ritz BW: Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: A randomized, multicenter, double blind, placebo controlled clinical study. Clinical Rheumatology (2009): 28:907-914.

3 Danesch U, Seybold M, Rittinghausen R, Treibel W, Bitterlich N: NEM brand eggshell membrane effective in the treatment of pain associated with knee and hip osteoarthritis: Results from a six-center, open-label German clinical study. J Arthritis (2014) 3:3.

4 Benson KF, Ruff KJ, and Jensen GS: Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-levels after in-vitro digestion. J Med Food (2012) 15(4):360-368.

5 Ruff KJ and DeVore DP: Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Modern Research in inflammation (2014) 3:19-25.

6 Bauer KL, Dierenfeld ES, and Hartup BK: Evaluation of a nutraceutical joint supplement in cranes. Proc N Amer Crane Workshop (2014) 12:27-32.

7 E.S. Dierenfeld, D. Baumb, L. Hampec, J. Jensenb, C. Atwe, and K. Wedekind: Evaluation of a Nutraceutical Joint Supplement in Camels. Amer Holistic Vet Med Assoc J (2014) 36:59-66.