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New Study Confirms Supplementation with MemreePlus PS Can Reduce Stress Responsivity in Chronically Stressed Subjects
Anew study confirms that supplementation with MemreePlus, Lonza’s proprietary blend of soy-based phosphatidylserine (PS) and phosphatidic acid (PA), can decrease the stress response in chronically stressed male adults. The findings were published in Lipids in Health and Disease and can be found here: www.lipidworld.com/content/ 13/1/121/abstract.1
Seventy-five healthy male adults were enrolled in this double-blind, randomized, placebo-controlled study, stratified by chronic stress level, and randomly allocated to one of three study arms. After six weeks of supplementation, participants completed the Trier Social Stress Test (TSST). This test is a combination of a job interview style presentation followed by a math challenge, designed to provoke a certain stress response. Stress biomarkers were assessed before and at certain time intervals after the TSST. Compared to placebo, supplementation with a daily dose of MemreePlus providing 400 mg PS and 400 mg PA, was effective in normalizing the ACTH (p = 0.010), salivary (p = 0.043) and serum cortisol responses (p = 0.035) to the TSST in chronically high but not in low stressed subjects (all p > 0.05).
Chronic mental stress can lead to adverse physiological and psychological outcomes. Physiological outcomes are typically related to a dysregulation of the stress hormone cortisol. In acutely stressful situations, cortisol helps increase glucose availability, blood pressure and mental performance. Over time, however, chronically high levels of cortisol can lead to impaired glucose tolerance, increased risk for weight gain, decreased immune responses and memory impairment.
“This new study further validates the use of MemreePlus to help with stress reduction,” says Matthias Rüsing, PhD, global product manager for the Memree product line at Lonza. “This is in addition to evidence from 2004, when a double-blind, placebocontrolled trial found that three weeks of supplementation with a MemreePlus supplement can significantly decrease levels of cortisol and distress after a stress test, as compared to placebo.”2
Lonza is a leading supplier to the pharmaceutical, biotech and specialty ingredients markets. The company harnesses science and technology to create products that support safer and healthier living and that enhance the overall quality of life.
Not only is Lonza a custom manufacturer and developer, the company also offers services and products ranging from active pharmaceutical ingredients and stem-cell therapies to drinking water sanitizers, from the vitamin B compounds and organic personal care ingredients to agricultural Products, and from industrial preservatives to microbial control solutions that combat dangerous viruses, bacteria and other pathogens.
Founded in 1897 in the Swiss Alps, Lonza today is a well-respected global company with more than 40 major manufacturing and R&D facilities and approximately 10,000 employees worldwide. The company generated sales of about CHF 3.6 billion in 2013 and is organized into two marketfocused segments: Pharma&Biotech and Specialty Ingredients. Further information can be found at www.lonza.com.
1 Hellhammer J, Vogt D, Franz N, Freitas U, Rutenberg D (2014). The soy-based phosphatidylserine/ phosphatidic acid complex MemreePlus normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: A randomized, placebo-controlled study. Lipids Health Dis 13:121.
2 Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. (2004). Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 7(2):119-126.