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Sabinsa Corporation: 2016 Science of Ingredients

20 Lake Dr.
East Windsor, NJ 08520
Phone: (732) 777-1111 • Fax: (732) 777-1443
Email: info@sabinsa.com
Website: www.sabinsa.com

LactoSpore

Sabinsa’s LactoSpore is a shelf stable microbial preparation from Lactobacillus sporogenes (Bacillus coagulans, MTCC 5856). The normal human digestive tract contains about 400 different bacteria that help reduce the growth of harmful bacteria. Among them, the largest group of bacteria in the intestine is the lactic acid producing bacteria. LactoSpore produces L(+) lactic acid and grows in the temperature range of 35°C to 50°C and an optimum pH range of 5.5-6.5.

Current lifestyle conditions are stressful, effecting human health in multiple ways. Stress may be caused by sudden changes in food-consumption patterns, exposure to environmental pollutants, life events, or extensive travel. Under such adverse circumstances, an imbalance is created in the system that may cause harmful bacteria to become predominant. This often impairs normal gut function and leads to various problems, ranging from inefficient digestion, diarrhea, constipation and flatulence to severe gastrointestinal disorders.

A logical and effective approach to restoring the balance of intestinal flora is the use of probiotics. A well recognized, superior and potential probiotic is a species among Lactobacillus – L. sporogenes. This species remains in its natural sporulated form, which on activation in the acidic environment of the stomach can germinate and proliferate in the intestine to produce the favored L (+) form of lactic acid and effectively prevent the growth of other pathogens.

Sabinsa supplies LactoSpore of following strengths:

• 6 billion spores/g
• 15 billion spores/g

Advantages

Preparations of LactoSpore in various dosage forms such as tablets, capsules, granules or powder have the following benefits over many other probiotics:

1. The natural sporulated form enables them to be more thermo-stable and retain viability through processes such as spray drying during preparation and during storage before consumption.

2. This also enables them to survive in gastric secretions and bile of the upper digestive tract to reach the intestine safely.

3. Once established in the digestive tract they produce lactic acid and other antagonistic substances to inhibit the growth of pathogenic bacteria and improve digestive health.

Stability in Functional Foods

Probiotics are widely accepted when incorporated in functional foods. With stability a common concern, LactoSpore’s shelf stable spore form has allowed successful incorporation in various functional foods. Its stability in baked muffins and waffles, hot beverages such as coffee, frozen fudge frostings and toppings and beverages such as apple juice and glucose syrup has been evaluated, with LactoSpore showing stability during processing and storage. (Majeed M et al., 2016. International Journal of Food Science and Technology. doi:10.1111/ijfs.13044)

Gastrointestinal Health Benefits

Irritable bowel syndrome (IBS) is a common disorder that affects the colon, causing symptoms such as cramping, abdominal pain, bloating, gas, diarrhea and constipation. The effect of LactoSpore in offering relief to patients suffering from IBS has been clinically evaluated in a randomized, double blind placebo controlled study. The study showed a significant decrease in symptoms like bloating, vomiting, diarrhea, abdominal pain and stool frequency in the group receiving LactoSpore. A decrease in severity and improvement in quality of life was also observed. (Majeed M et al., 2016. Nutrition Journal. DOI 10.1186/s12937-016-0140-6)

Safety

The safety of LactoSpore in healthy volunteers has been established through a human clinical trial. A dosage of two billion spores of LactoSpore once daily was given to 40 healthy human volunteers for 30 days and analyzed for laboratory parameters (blood hematology and clinical chemistry parameters), anthropometric measures (weight, BMI, blood pressure and heart rate), adverse events, Bristol Stool Score, tolerability questionnaire and bowel habit diary. LactoSpore was established to be safe and tolerable in healthy participants on evaluation of all the above parameters (Majeed M et al., 2016. J Clin Toxicol. doi:10.4172/2161-0495.1000283).

Topical benefits

Probiotics play an essential role in skin care as well, which has been clinically established through recent studies. LactoSpore has been incorporated successfully for supporting healthy skin topically in products such as soaps. While it imparts a positive effect on skin by modulating mechanisms related to the immune system, it also provides benefits for atopic conditions by restoring residential and beneficial skin microflora. (Majeed M et al., 2015. EuroCosmetics 10-11).