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Xsto Solutions, LLC: 2016 Science of Ingredients

Once Again Nut ButterNOW Private Label

45 S. Park Pl., Ste. 148
Morristown, NJ 07960
Phone: (973) 975-4224 • Fax: (973) 545-0221
Email: info@xstosolutions.com
Website: www.xstosolutions.com

Cuvitus New for Muscle and Joint Support

Muscle and joint pain can range from minor and annoying to significant and debilitating. To most people the cause is really less important than finding relief during the period of discomfort. Generally there is temporary pain and discomfort from short term over exercise or exertion and there is chronic or long-term pain from disease conditions such as arthritis. Dietary supplement claims are limited to marketing only to the pain and discomfort associated with the “temporary activities” versus ongoing conditions. Short term “over exercise” includes activities such as running a mini marathon or working in the yard all weekend, which can lead to muscle and joint pain. By doing something (or overdoing something) that we don’t routinely do on a daily basis we meet the “temporary” criteria. Using muscles we don’t normally use often causes soreness and pain the next few days. Metabolically we are increasing specific pro-inflammatory cytokines such as TNF-alpha and certain interleukins, which have been scientifically linked to the process of pathological pain.1 Using these cytokines as “biomarkers” for pain we can begin to track whether a compound will beneficially reduce pain and soreness from temporary over exercise or exertion.

Cuvitus Efficacy for Pain

With this in mind, recent scientific research out of Europe has focused on a newly isolated compound extracted from the Cucumis sativus fruit, commonly referred to as cucumbers. Cucumbers have long been appreciated for their cooling and soothing effect for sunburn skin and puffy eyes. They have also been a staple of many diets for their refreshing and low calorie properties. With a unique extraction process, the active beneficial compounds of the Gherkin cucumber have been commercialized as Cuvitus, an exciting new ingredient for use in nutrition and dietary supplementation.

The initial scientific research looked at in vitro studies where cells were stressed using LPS (lipopolysaccharide), a popular model for initiating cellular stress and observing the “normal” response of cell proliferation. Cells exposed to the Cuvitus extract showed lower proliferation of TNF-α and certain interleukin cytokines thought to be a result of cellular nuclear translocation of NF-kβ.2 Additional studies on animal and human cells (ex-vivo) confirmed the in vitro research.

In the first human study, athletes form the Italian Army Carabinieri Olympic Track and Field team participated in a yearlong study observing “a reduction in pain level” from training as the benefit of Cuvitus on muscle pain. In this open label study, 65 percent of the athletes reported positive effect versus 10 percent or less reporting supplementation had little or no effect.3 In a second human observational study over a non-statistically relevant population of adult people (more than 21 years of age), the participants were followed by 10 physicians, for a treatment period of 10 to 30 days. The 50 subjects enrolled in the study suffered from various type of acute or chronic pain. Almost 40 percent of the participants reported “strongly positive” benefit and 80 percent of participants reported results as “positive” and “strongly positive.”4 In each human study the participants were given between one and four doses at 150 mg each. It was later determined that two doses (300 mg) where probably adequate for the response.

Safety of Cuvitus

While cucumbers have been consumed safely by humans for centuries, one has to ask if an extract of the same fruit, with its potential concentrations, are equally as safe? To confirm the safety profile, Cuvitus gherkin extract has been tested for safety using acute toxicity formats as well as mutagenic and cytotoxicity platforms. No toxic properties were observed and no abnormal findings were recorded in any of the three toxicoloty study formats.

The cuvitus compound is a free flowing tan colored powder, which can be easily formulated in tablets and capsules. The researched dose is 150 mg with a recommendation of one or two doses per day. The loading time is two to three days and there have been no reported side effects and no adverse events. Cuvitus is a soothing tonic for muscle and joint pain from temporary over exertion and exercise. Contact Xsto Solutions at info@xstosolutions.com or visit the company’s website at www.xstosolutions.com.


1 Intl Anethesial Clin. 2007 Spring:45(2) 27-37.

2 Inflamm. Res. (2013) 62:461-469.

3 Unpublished data from Crown Health Gherkin, Lugano, Switzerland 2013.

4 Unpublished Data from Crown Health Gherkin, Lugano, Switzerland 2014.