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2015 Supply Innovation: Biova, LLC

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Biova LLC

Kansas Bioscience Authority Bldg.
10900 S. Clay Blair Blvd., Ste. 1000
Olathe, KS 66061
Phone: (877) OVACORE; (913) 815-4049
Email: clear@biova.com
Website: www.biova.com

What’s New on the Joint Horizon?

Egg membrane is making a strong case for being the next go-to ingredient.

The market for joint health supplements continues to grow as an aging and more active population seeks natural support and pain relief. Growing demand combined with market research showing slowing interest in traditional glucosamine and chondroitin formulas, translates into plenty of opportunities in the joint health ingredient marketplace.1

“Although glucosamine and chondroitin have been the requisite joint health combo for years, they’re starting to show their age,” said Matt Stegenga, president of Biova, the U.S. company that manufactures BiovaFlex water-soluble egg membrane (WSEM). “We’re finding that consumers are not only looking for something new, they want products with demonstrated fast results—BiovaFlex is just such an ingredient.”

And the scientific efficacy research is there to support BiovaFlex’s continued market growth.

A recently published study shows taking a daily 450 mg dose of BiovaFlex was associated with improved joint range of motion (ROM) in multiple areas including the neck, back, hips, shoulders and knees. Study participants reported increased physical energy and activity levels. And subgroup analysis showed reduction of back pain—as one might experience from exercise and/or daily activity—after just five days.2

The article, “Support of Joint Function, Range of Motion, and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate,” is based on the randomized, double-blind, placebo-controlled, crossover study conducted by NIS Labs, Klamath Falls, OR. It was published in the September 2015 Journal of Medicinal Food.

“This research is compelling for several reasons, but what’s most powerful is that people say they feel better when taking BiovaFlex,” said Stegenga. “Everyone wants to enjoy their daily activities, whether it’s exercise or chores or just day to day living. The empirical data collected during this study are important. We love that our product demonstrated fast, five-day relief to back pain. And we’re happy that people report being able to be more active, enjoy life with BiovaFlex.”

Another important aspect of the most recent BiovaFlex research is that it focused on a study population with no diagnosis of joint diseases.

“The study reflects broad improvements, independent of a person’s identified chronic joint and mobility problems,” Stegenga said. “The article concluded, that with more research, WSEM might hold future promise as a natural support for the joints of older populations, athletes and patients recovering from joint and muscle injuries.”

The research article can be found online at biova.com/research or at the Journal of Medicinal Food.

Stegenga also points out that relief doesn’t have to come in a pill. Biova’s patented-process WSEM ingredients allow for expanded delivery options for consumer products far beyond traditional tablets and capsules.

“Research shows 40 to 70 percent of adults report issues3 with swallowing pills or tablets,” said Stegenga. “Why not formulate a consumer product that dissolves completely in water? Or create a gummy that can be chewed and easily swallowed? BiovaFlex delivers these options to formulators. We want to help our customers innovate, to look at what’s new, to be unconventional and more successful with consumers.”

With a uniform ingredient profile, including standardized ≥88 percent protein, Biova’s Hydro5 patented process makes egg membrane water soluble while maintaining the natural ratio of complex proteins including glycosaminoglycans, collagen, elastin, desmosine and isodesmosine.

“Our Hydro5 and OvaPure processes allows us to produce very uniform and pure, low-ash, high-protein water soluble egg membrane ingredients every time,” said Stegenga. “And offering water solubility, we’re an innovative alternative delivery solution for formulators.”

Founded in 2005, Biova is the market leader for water soluble egg membrane (WSEM) ingredients offering proven health benefits: BiovaFlex for joint health; BiovaDerm for skin care; and BiovaPlex for animal health.

“We knew from the very beginning that our WSEM ingredients would offer formulators something unique,” said Stegenga. “We’re providing new, exciting ingredients that can be used in new, exciting ways.”

Biova’s patented water soluble process creates expanded delivery options for consumer products, including functional foods, beverages, lotions and more. A focus on sustainable production, anchored by vertical integration with some of the largest U.S.-domestic egg producing and processing partners, assures Biova unmatched raw material supply—the right combination of access and capability to drive opportunity and growth worldwide.

“We’ve dedicated years of investment, scientific research and leading-edge technology bringing these ingredients to market,” said Stegenga. “Based on the reception we’ve seen—around the world—it’s really starting to pay off.”


1 Nutrition Business Journal—Global Supplement Nutrition Industry Report 2014; figure 4-16; section 4.2.1; 2014 Penton Media, Inc.

2 Jensen, Gitte S., Miki R. Lenninger, Joni L. Beaman, Robert Taylor, and Kathleen F. Benson. “Support of Joint Function, Range of Motion, and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate,” Journal of Medicinal Food September 2015, 18(9): 1042-1048. doi:10.1089/jmf.2015.0041.

3 Hermes Pharma. “A Hard Truth to Swallow.” Accessed October 19, 2015. www.swallowingtablets.com.