2015 Supply Innovation: Sabinsa Corporation
uC3 CLEAR: Raise a Glass to Curcuminoids
Curcuminoids, the versatile, cascading and long-lasting pronutrient is undoubtedly the most important and precious gifts to mankind from nature. A common spice used in South Asian cooking, turmeric and more appropriately, the component curcuminoids, have been preclinically and clinically validated for their beneficial role in maintaining health and wellness. They offer antioxidant support, anti-inflammatory support, support for a healthy immune system, and the potential to prevent connective tissue break down through inhibiting destructive enzymes, with benefits in healthy aging.
At the molecular level, curcuminoids have been shown to inhibit nuclear factor kappaB (NFkB), a transcription factor that triggers inflammatory mediators. NFkB is implicated in a variety of chronic disease conditions ranging from cardiovascular diseases to cancer.
While more than 45 human clinical studies have been published and continue to emphasize the relevance and importance of curcuminoids in general health and wellness; more than 50 pre-clinical studies have also been carried out for a range of applications, unraveling the mechanisms at the cellular level.
Sabinsa has more than 26 years experience in the field of standardized extracts and with the chemistry and properties of turmeric. The team of scientists at Sabinsa, while working on this traditional herb, turmeric, derived an optimized composition of curcuminoids from rhizomes of turmeric to provide the maximum antioxidant or bioprotectant activity. This composition was later patented by Sabinsa. This unique and patented composition of curcuminoids is available under the brand name, Curcumin C3 Complex. Curcumin C3 Complex achieved a major landmark in 2013 when it received “no comment letter” from the FDA (U.S. Food and Drug Administration), which meant that Sabinsa’s Curcumin C3 Complex achieved GRAS (generally recognized as safe) status and now could be used in food categories as well.
With all the above benefits, delivery of curcumin in the form of a drink has always been a challenge due to poor solubility resulting in sedimentation. Several methodologies have been attempted by many to improve the solubility, such as use of polymeric substances, nano particle synthesis, lipophilic formulations and so on. The safety of these forms of curcumin and their excipients to increase the solubility has always been an issue of concern.
uC3 CLEAR is an improved, convenient delivery system for curcumin that overcomes the basic challenges and limitations that can be present with solid dosage delivery systems such as poor disintegration, slow dissolution, or difficulty swallowing, thus enhancing the uptake of curcumin.
Sabinsa’s uC3 CLEAR is:
• Water soluble
• A compatible form of curcuminoids in beverages
• Free from nano-technology
• Visually appealing
The use of standardized extracts in different dosage forms such as tablets, capsules and soft gels is well known. However, their incorporation in functional foods and beverages is in recent times more widely accepted and preferred. The challenge is to solubilize plant based extracts that are safe, effective and compatible in beverages.
With this background, the development of uC3 CLEAR is the culmination of a wide range of experiments that have gone into formulating a water soluble form of curcumin. With equal and vast knowledge on scientifically validated natural extracts and the formulation of functional foods using these ingredients, Sabinsa has delivered its water soluble curcumin extract—uC3 CLEAR.
uC3 CLEAR is standardized for 10 percent curcuminoids, and forms clear solution with water. Curcumin with its multifaceted biochemical mechanisms and in its water-soluble form remains the unparalleled natural molecule of interest—in the past, present and future.
With all the health and wellness benefits of natural curcuminoids packed in a compatible form, uC3 CLEAR is here to deliver one of the most powerful natural extracts of the century.