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2017 Science of Ingredients: Natreon, Inc.

Once Again Nut ButterNOW Private Label

2D Janine Pl.
New Brunswick, NJ 08901
Phone: (732) 296-1080 • Fax: (732) 917-7634
Email: info@natreoninc.com
Website: www.natreoninc.com

Purified Shilajit for Collagen Synthesis and Anti-aging

There are many theories on the aging process, but a growing body of scientific evidence now suggests that mitochondrial DNA damage is a major factor in aging. Mitochondria, also known as the “powerhouse” of all cells in the human body, functions to produce adenosine triphosphate, or ATP, which in turn provides energy for most activities within the cell.1 The process of cellular metabolism leads to the production of reactive oxygen species (ROS), a set of highly active free radicals.1 The mitochondria are the sites of the highest ROS production in the cell which exposes the mitochondrial DNA to oxidative damage.1 Accumulation of oxidative damage caused by ROS and mutations of DNA lead to acceleration of the aging process.1

Shilajit, an organic substance harvested from the Himalayas,2 is long known in ayurvedic medicine for its healing powers. In fact, British archaeologists found evidence of its use by the Indus Valley Civilization (3000 B.C.). It acts as a powerful adaptogen, providing broad systemic defense against stress and illness.2 PrimaVie, a standardized extract of Shilajit manufactured by Natreon, has proven to be useful in energy metabolism and believed to have rejuvenating activity in different debilitating states in humans. PrimaVie is comprised of mainly fulvic acids and DBPs (dibenzo-α-pyrones). Fulvic acid independently stimulates mitochondrial energy metabolism, protects mitochondrial membranes from oxidative damage, and helps channel electron-rich DBPs into the mitochondria to support the electron transfer chain.2 Several clinical studies have shown that PrimaVie can boost mitochondrial energy, improve exercise performance, and increase testosterone levels.3-6 It has shown to increase ATP synthesis and protects coenzyme Q10 from degradation by oxidative free radicals in the mitochondria.3-6

One aspect of the aging process is the breakdown of collagen in the skin and bones. Collagen is a protein found in the fibrous tissues, like the skin, ligaments and tendons. It can also be found in the bones, cornea of the eyes and the blood vessels. Collagen strengthens the blood vessels and gives skin its elasticity. Collagen destruction can result from exposure to free radicals. Therefore, antioxidants, such as PrimaVie Shilajit, are necessary to prevent the destruction of collagen. One recent clinical study showed PrimaVie to up-regulate many of the genes responsible for the synthesis of collagen and related extracellular matrix proteins by several fold, thus suggesting its role in the anti-aging process.7

With age, there is a decrease in collagen production and an increase in collagen degradation. These changes result in the characteristic signs of aging, such as loss of elasticity in the skin, appearance of wrinkles and fine lines. This latest study now proves that PrimaVie Shilajit has a significant role in collagen and related extracellular matrix protein gene expression, thus suggesting its role in the anti-aging process. In addition, since the genes studied were from the thigh skeletal muscle, PrimaVie will be of immense value in sports nutrition.


1 Kang HT, Hwang ES. Aging Cell. 2009;8(4):426-438.

2 Ghosal S. Shilajit in Perspective. Oxford, U.K.: Narosa Publishing House; 2006.

3 Bhattacharyya S, Pal D, Banerjee D, et al. Shilajit dibenzo-α-pyrones: Mitochondria targeted antioxidants. Pharmacologyonline. 2009; 2:690-8.

4 Pal D, Bhattacharya S. Pilot Study on the Improvement of Human Performance with ReVitalET as Energy Booster: Part-IV. 2006. Data on file. Natreon, Inc.

5 Clinical study for evaluation of safe use in purified and standardized Shilajit in normal volunteers. J. B. Roy State Ayurvedic Medical College and Hospital, Kolkata. 2007. Data on file. Natreon, Inc.

6 Clinical study for evaluation of plasma antioxidant capacity and safe use of purified and standardized Shilajit (ReVitalET) in normal volunteers. J. B. Roy State Ayurvedic Medical College and Hospital, Kolkata. 2007. Data on file. Natreon, Inc.

7 Roy, S. Human Skeletal Muscle Extracellular Matrix Fortification in Response to Oral Supplementation with PrimaVie Shilajit. Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA Journal of Medicinal Food J Med Food 19 (7) 2016, 701–709.

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