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2017 Science of Ingredients: OmniActive Health Technologies, Inc.

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CurcuWIN As an Adjunct for Sports Nutrition

Sports nutrition has evolved to reflect the fact that building stronger muscles, performing better and recovering faster requires more than just exercising hard and ingesting protein. Working muscles have specific nutritional needs that need to be addressed to optimize exercise performance and recovery. The cornerstone of any sports supplement protocol starts with optimizing cardiovascular function for more efficient transportation of blood, oxygen and nutrients to working muscles and effective removal of lactate and carbon dioxide to allow athletes to maintain higher intensities for longer. The ability of the cardiovascular system to adapt to increased nutritional demands during exercise is regulated by a complex of compound—most notably nitric oxide (NO)—that influences vasodilation and increased blood flow. And that process begins in the endothelium.

The endothelium is the innermost layer of the blood vessel wall. It plays a critical role in the proper functioning of the cardiovascular system by regulating vascular homeostasis.1-3 When blood flow increases through a vessel, the vessel dilates. This process is tightly regulated by the endothelium and the hallmark of impaired functioning of the endothelium is the inability of blood vessels to expand in response to various stimuli like physical activity.1 In healthy blood vessels, endothelium-dependent dilation predominates and is primarily regulated by NO produced by endothelium-derived NO synthase (eNOS). Therefore, decreased production of NO, manifested as impaired dilation, can impair blood flow and availability of oxygen and nutrients. Therefore, to optimize exercise performance it becomes important to understand the relationships between NO, endothelial function and natural compounds that can support a healthy endothelium.

FloMeD Study: CurcuWIN Supports Healthy Vascular Function

OmniActive’s FloMeD study measured the direct impact of CurcuWIN on healthy circulation using flow mediated dilation (FMD)—a process that measures the ability of blood vessels to dilate and is a useful tool to assess endothelial function.4,5 As a randomized, double-blind, placebo-controlled, prospective study, 59 healthy individuals aged 19 to 29 years were supplemented with either placebo, 50 mg curcuminoids (250 mg CurcuWIN) or 200 mg curcuminoids (1,000 mg CurcuWIN) for eight weeks.

Supplementing with 200 mg curcuminoids from CurcuWIN showed a statistically significant 37 percent improvement in FMD over placebo. The fact that there was a significant improvement in FMD in healthy subjects supplementing with CurcuWIN demonstrates its clinical significance in improving cardiovascular health and its potential as an adjunct for muscle performance. When compared to other studies on natural compounds, such as soy, L-arginine, fish oil and cocoa, CurcuWIN showed a greater improvement in FMD.6-9

Increased Absorption and Retention Correlates to Efficacy at a Lower Dose

The bioavailability of orally administered curcumin is quite poor often requiring high dosages to elicit a clinical response. CurcuWIN uses Ultrasol technology; a molecular dispersion process that converts lipophilic nutrients into water-dispersible ingredients to enhance bioavailability and retention. The results of the Jager study show that CurcuWIN has 46-times higher relative absorption and retention than standard curcumin after 12-hours post supplementation.10 The combination of improved bioavailability and extended retention in the body may explain CurcuWIN’s cardiovascular benefits in a healthy population at a lower dosage.

References:

1 Davignon J and Ganz P. (2004). Role of endothelial dysfunction in atherosclerosis. Circulation, 109(23 Suppl 1): III27-32.

2 Luscher Tf, et al. (1997). Biology of the endothelium. Clin Cardiol, 20: 11-3-11-10.

3 Kinlat S, et al. (2001). Endothelial function and coronary artery disease. Curr Opin Lipidol, 12: 383-389.

4 Oliver J, et al. (2016). Novel form of curcumin improves endothelial function in young, healthy individuals: a double-blind placebo controlled study. J Nutr Met, 2016: 1-6. Downloaded at http://dx.doi.org/10.1155/2016/1089653

5 Moens AL, et al. (2005). Flow-mediated dilation. A diagnostic instrument or an experimental tool? Chest, 127(6):2254-63.

6 Li SH, et al. (2010). Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials. Am J Clin Nutr, 91(2): 480-6.

7 Bai Y, et al. (2009). Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 89(1): 77-84.

8 Xin W, et al. (2012). Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized controlled trials. PLoS One., 7(9): e46028.

9 Hooper L, et al. (2012). Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr, 95(3): 740-51.

10 Jäger R, et al. (2014). Comparative absorption of curcumin formulations. Nutrition Journal, 13(1): 11.

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