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IgY Nutrition LLC: 2016 Science of Ingredients

6520 N. Western Ave.
Oklahoma City, OK 73116
Phone: (405) 242 5387
Email: info@igynutrition.com
Websites: www.igynutrition.com,
www.hyperimmunegg.org, www.igymax.com

IgY Max Specifically Immunized Egg for optimal GI Health

By Susan J Hewlings PhD, RD

Recent research suggests that that the typical ‘Western’ diet consisting of a high fat, high sugar, low fiber intake, has altered the diversity of the human gut microbiome leading to dysbiosis.1 Dysbiosis is defined as a shift in the microbiota composition resulting in an decrease in the number of beneficial microbes accompanied by an increase of harmful microbes in the intestinal tract.2 Diet induced dysbiosis is thought to contribute to many diseases including metabolic syndrome, diabetes, cancer, inflammatory conditions, neurological pathologies and psychiatric disorders.1,3 These changes not only occur over the long term intake of such a diet, but can occur in a single day.1 Because of the increased awareness of dysbiosis and its negative effects, there has been increased consumer demand for pro- and prebiotics in the dietary supplement, nutraceutical and dietary ingredient markets. It has been suggested that probiotics may play a role in correcting the dysbiosis. However, they are strain specific and since dysbiosis can present differently in each person they may not always address the imbalance.2 Prebiotics may offer an alternative or symbiotic benefit to probiotics as they have been used to stimulate beneficial bacteria to help to restore balance. In contrast to the probiotic action, which provides living microorganisms, prebiotics stimulate the activity of healthful bacteria. A prebiotic is defined as “a selectively fermented dietary ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host health.”2

IgY Max is much like a prebiotic in that it changes the composition and activity of the microbiome. Countless intestinal microorganisms comprise our intestinal microbiome, where they serve to aid in digestion, supply important nutrients and vitamins, and provide immune function. When unwelcome bacteria are present, the space for good bacteria is limited. Think of a garden overrun with weeds. Just like the weeds, pathogens leave no room for beneficial flora to grow, taking up vital nutrients needed to survive. IgY antibodies contained in IgY Max help the body eliminate only the harmful bacteria and leave the good microbes intact.

IgY antibodies are antibodies from chicken eggs. They work by significantly reducing harmful bacterial adhesion and growth in the GI (gastrointestinal) tract, thereby helping to minimize inflammation by decreasing cytokines and HSCRP. IgY antibodies offer several advantages over mammalian IgG antibodies: they have a three to five times higher immunogenicity, they do not increase inflammatory cytokines, and they have a 20 times higher immunoglobulin concentration per unit. Moreover, IgY antibodies have a highly specific rapid and local onset of action, are non-toxic,10 and they do not stimulate the human complement system thus preventing non-specific inflammation. Antigen-specific IgY products have been shown to be effective in promoting gut function and immunity in humans,11 as well as in reducing the side effects of dysbiosis.12 IgY Max is a polyvalent antigen specific IgY product targeting 26 of the most common human-relevant pathogens. Other IgY products only target one pathogen and therefore are monovalent. IgY Max is a unique digestive and immune function ingredient that promotes GI health by increasing gut wall integrity,13 improving bowel function,12 and reducing non-beneficial bacteria adherence, and in doing so functions much like a prebiotic. However, it is slightly different than a prebiotic in that it in addition to favorably altering the composition of the microbiome, it supports the digestive tract lining, promotes proper microbial adhesion, supports immune system health, supports the body’s natural defenses and promotes proper cytokine balance. Moreover IgY Max is able to exert its activity within the entire length of the GI tract.10 Due to its mechanism of action IgY Max is an effective tool to address issues caused by dysbiosis.

IgY Max is a safe and viable option for anyone who wants to maintain and improve total GI function. Made from whole eggs that have been spray dried but otherwise unaltered, IgY Max is GRAS (self affirmed, generally recognized as safe) and holds a Master Food Additive file number. IgY Max as a stand-alone product is NSF Certified for Sport. Available exclusively from IgY Nutrition, IgY Max is a unique dietary supplement that provides optimal digestive function through the power of IgY and passive immune technology. By reducing competition in the gut, IgY Max provides enough room for probiotics to grow. Don’t let bad bacteria condemn your health; use IgY Max to support your microbiome.

References:

1 David LA, et.al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014;505:559-578.

2 Ducatelle R, et.al. A review on prebiotics and probiotics for the control of dysbiosis: present status and future perspectives. Animal. 2015; 9(1):43–48.

3 Distrutti E, Monaldi L, Ricci P, Fiorucci S. Gut microbiota role in irritable bowel syndrome: New therapeutic strategies. World J Gastroenterol. 2016; 22(7): 2219-41.

4 Di Bartolomeo, F., Startek, J.B. and Van den Ende, W. Prebiotics to Fight Diseases: Reality or Fiction?. Phytother. Res.2013; 27: 1457–1473.

5 Cummings J, Antoine J, Azpiroz F et al. PASSCLAIM1-Gut health and immunity. European Journal of Nutrition. 2004;43(S2): II/118–II/173.

6 Kamada N, Chen G, Inohara N, Núñez G. Control of pathogens and pathobionts by the gut microbiota. Nature Immunology. 2013;14(7):685-690.

7 Chalghoumi R, Théwis A, Beckers Y, Marcq C, Portetelle D, Schneider YJ. Foodborne Pathog Dis. 2009; 6(5):593-604.

8 Rahman S, et.al. Oral passive IgY based immunotherapeutics. Human Vaccines and immunotherapeutics. 2013;9(5):1039-1048.

9 Miles, Laura. Effects of Hyperimmune Eggs on HSCRP Levels: Results of a private clinical trial. Unpublished study.

10 Munhoz LS, et.al. Avian IgY antibodies characteristics and applications in immunodiagnostics. Cienca Rurall. 2014; 49(1):153-160.

11 Kovacs-Nolan J, Mine Y. Egg yolk antibodies for passive immunity. Annu Rev Food Sci Technol. 2012;3:163-187.

12 Jacoby, H. Moore, G. Wnorowski, G. Inhibition of diarrhea by immune egg: a castor oil mouse model. Journal of Nutraceuticals, Functional & Medical Foods, 2001;3(2):47-53.

13 Ambekar R. Effect of a nutritious drink fortified with immune egg in improving the weight and enhancing the well-being of subjects. Unpublished study.1998.