Gut on a Chip

Microchips lined by human intestinal cells revolutionizes microbiome analyses. A human gut-on-a-chip micro-device was used to co-culture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a week in vitro and to analyze how gut microbiome, inflammatory cells, and peristalsis-associated mechanical deformations independently contribute to intestinal bacterial overgrowth and inflammation. ...