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1 Ahn, H.; Kim, J.; Lee, M.-J.; Kim, Y.J.; Cho, Y.-W.; Lee, G.-S. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine 2015, 71, 223–231.

Non-GMO Project

2 Kloesch, B.; Liszt, M.; Broell, J.; Steiner, G. Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2. Life Sci. 2011, 89, 473–478.

3 Kim, Y.; Kim, D.; Lim, H.; Baek, D.; Shin, H.; Kim, J. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol. Pharm. Bull. 2009, 32, 651–656.

4 Kobayashi, M.; Squires, G.R.; Mousa, A.; Tanzer, M.; Zukor, D.J.; Antoniou, J.; Feige, U.; Poole, A.R. Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage. Arthritis Rheumatol. 2005, 52, 128–135.

5 Melcher, D.A.; Lee, S.-R.; Peel, S.A.; Paquette, M.R.; Bloomer, R.J. Effects of methylsulfonylmethane supplementation on oxidative stress, muscle soreness, and performance variables following eccentric exercise. Gazz. Med. Ital.-Arch. Sci. Med. 2016, 175, 1–13.

6 Van der Merwe, M.; Bloomer, R.J. The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise. J. Sports Med. 2016, 2016, 7498359.

7 Kalman, D.S.; Feldman, S.; Samson, A.; Krieger, D.R. A randomized double blind placebo controlled evaluation of msm for exercise induced discomfort/pain. FASEB J. 2013, 27, 1076–1077.