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Natural Ingredients Tackle Pain and Inflammation

Pain and Inflammation Pain and Inflammation

The panel:

Denis Alimonti, Director of U.S. Nutrition, Maypro, Purchase, NY, www.maypro.com

Abdul Alkayali, Vice President, Sales and Marketing, Certified Nutraceuticals, Pauma Valley, CA, www.certifiednutra.com

Tim Hammond, Vice President of Sales and Marketing, Bergstrom Nutrition, Vancouver, WA, https://optimsm.com

Shil Kothari, Chief Executive Officer, IminoTech Inc., Carson City, NV, www.iminotech.com

Michael Lelah, PhD, Chief Science Officer, NutriScience Innovations, Milford, CT, https://nutriscienceusa.com

Maggie McNamara, Marketing Director, Gencor Pacific, Austin, TX, www.gencorpacific.com

Eric Meppem, Commercial Director, Pharmako Biotechnologies, New South Wales, Australia, www.pharmako.com.au

Jim Roza, Chief Scientific Officer, Layn Natural Ingredients, Irvine, CA, https://layncorp.com

Vishal Shah, Director, Nutriventia Limited, Mumbai, India, www.nutriventia.com

Liat Shemesh, Head of Marketing, Solabia-Algatech Nutrition, Kibutz Ketura, Israel, www.algatech.com

NIE: Please describe the state of the markets for natural pain remedies and natural inflammation remedies? Where are they now; where are they headed?

Lelah: With so many Americans dealing with acute and chronic pain issues, the field for natural pain-management products continues to grow. Though many do seek conventional treatments and pharmaceuticals, these don’t always work for those experiencing pain. Most individuals don’t want the side effects that often accompany conventional medicine either, which is why there is a significant rise in demand for products that can combat pain and discomfort with natural ingredients.

Kothari: The large market for natural solutions for pain and inflammation continues to grow. One of the largest segments is joint health, particularly older consumers who are concerned about the long-term effects of pharmaceuticals. Another growing consumer demographic is people struggling with excess body weight, obesity and metabolic imbalances.

However, natural products face limitations because pain relief usually, and inflammation relief almost always, are viewed as disease claims. Opportunities to increase product recognition and market share are driven by the nutritional cognoscenti, consumers who research the science of ingredients and share information.

McNamara: The natural pain remedy market is finally advancing. For decades the market was stuck due to no new or exciting ingredients. With advancements in technology, there seems to be a spike in consumer awareness and loyalty due to these innovations improving bioavailability and efficacy. Two great examples are HydroCurc and Levagen+. Both ingredients use patented technology to significantly improve bioavailability and formulation offerings (liquids, powders, gummies, etc.).

Currently, only non-steroidal anti-inflammatory drugs (NSAIDS) are well-known for “pain relieving” properties, however, there has been a lack of natural remedies—particularly those with good evidence of their efficacy in reducing pain and inflammation. That said, the awareness of the adverse effects of NSAIDs on the long-term health of the gut microbiome is increasing and thus the demand for natural alternatives is growing.

Omega-3s, curcumin, PEA, green tea, ginger, cat’s claw, devil’s claw, spirulina, resveratrol and zinc are all commonly known for their positive effects on inflammation—but the issue here is not whether these ingredients can work on inflammation; the issue is how effective are they due to delivery format and innovation. Not all ingredients are created equal and using branded, clean and clinically tested ingredients will help manufacturers stand out from the crowd.

Alkayali: The market for natural pain and inflammation remedies is intertwined with the markets for healthy aging, joint health, sports nutrition and others. Consumers of all ages desire pain and inflammation solutions because of a growing demand for non-pharmaceutical interventions. For ingredient manufacturers, age-related markets are the most targeted because more older consumers often have long-term needs for products that help address chronic pain and inflammation.

Shemesh: The risk of chronic inflammation increases with a variety of factors, such as obesity, unhealthy diet, inadequate exercise and stress and are very common in modern society. In recent years, as chronic inflammation has become a more well-known phenomenon, the consumption of supplements designed to reduce it has increased. We anticipate that this trend will continue to grow in the coming years.

Roza: Pain can affect people (and pets) of all ages, but with age, several health issues can bring about increased propensity for pain, including arthritis, muscle strains, pain associated with posture and alignment issues, and other reasons. Our global population is aging. According to the World Health Organization (WHO), By 2030, the population of people aged 60 years and over will increase from 1 billion in 2020 to 1.4 billion—and by 2050, the world’s population aged 60 years and older will double (2.1 billion)!

Inflammation plays a key role in pain management, and as today’s consumer is increasingly demanding more natural ingredients and remedies, we see the herbal industry responding with several science-backed, sustainable ingredient solutions. Natural, plant-based ingredients such as extracts of turmeric, green tea, pomegranate, cistanche, ginger and Sophora japonica have all been scientifically demonstrated to help support a healthy inflammation response.

Shah: In 2020, the global anti-inflammatory therapeutics market size was $98,026 million, and it is projected to reach $125,552 million by 2028. That is a CAGR (compound annual growth rate) of 4 percent. Many governments worldwide are taking positive initiatives to uplift the inflammation relief remedies market, especially in the region of Asia-Pacific and LAMEA, and these initiatives, I believe, will play an important role in contributing to overall market growth.

Largely, consumers worldwide are moving to natural inflammation-relief remedies because they find these alternatives to be more congruent with their own values and beliefs.

NIE: What are the main reasons so many consumers are suffering from chronic discomfort—diet, being overweight, lack of exercise, environmental causes or just living longer?

Hammond: Of course, it’s a complex combination of many factors that contribute to chronic discomfort. As such, it may be that some recent escalation of the issue is related to the pandemic and more sedentary lifestyles during that period. In addition, with biochemistry it is well known that ongoing chemical reactions in your body can contribute to aging no matter your genes.

Therefore, as we age, there is a nearly inevitable decline in health and functional capacity. Yet, when it comes to anti-aging behaviors, supplements work hand-in-hand with an individual’s choices to lessen the impact of aging through nutrition and fitness, along with other lifestyle modifications.

Alimonti: All of those are contributing factors with obesity being the most significant culprit. Americans are consuming processed meats, refined grains, snacks, sodas and fried foods at alarming levels. When you couple that with lack of exercise, you get increasing rates of obesity. Environmental chemicals—including cigarette smoke and pollution—make it all worse. We are living longer, but we are also developing chronic conditions marked by pain and inflammation that compromise quality of life and are rooted in poor nutrition, obesity and, to an unknown degree, environmental pollutants.

Roza: Aside from conditions associated with natural aging, diet, smoking, obesity mentioned above, stress and lack of sleep are also as conditions that can lead to chronic inflammation and discomfort. Sleep deprivation can give rise to an over expression of proteins such as protein kinase A and mitogen activated protein kinases MAPKs that can trigger pain as characterized by migraines. Elevated stress levels increase cortisol levels which can lead to inflammation, an increased heart rate and vasoconstriction which all have been implicated in causing pain. In addition to directly supporting a healthy inflammation response, other botanical extracts can also help support good sleep and healthy stress response, including holy basil, hemp, magnolia bark and white peony.

Lelah: Discomfort and fatigue are staggeringly common problems, with 65 million Americans reporting a recent episode of back pain. These issues have been exacerbated amid lifestyle changes due to the state of the world post-pandemic, making it even harder to perform necessary activities such as daily tasks, exercise and sleep. Spending long hours at work and maintaining hectic schedules can lead to a myriad of issues, including stress, discomfort and fatigue. These issues make it difficult to partake in the activities we enjoy most. Additionally, the increase in screen time for most Americans, combined with increased stress, leads to very little or very poor quality of sleep. Chronic lack of sleep can ultimately lead to extreme fatigue, which can cause injury and affect a person’s productivity.

Meppem: There are many reasons that people suffer chronic discomfort. The two most prevalent are probably modern lifestyle factors and chronic inflammation. Once people suffer discomfort, it can become a self-fulfilling prophecy, which can be a difficult cycle to break.

McNamara: Inflammation is the culprit of all diseases and ultimately many factors can contribute to this. We currently live in a society that, on average, lives in a pro-inflammatory state can mainly be attributed to the abundance of processed foods, lack of physical exercise and the increase in stressors of daily life (like COVID-19, war and economic uncertainty).

Lifestyle is the majority of the underlying cause. Poor diet leads to more inflammation, being overweight adds stress to the joints in the lower half of the body, and muscle weakness due to lack of movement/activity. Combine these three (which many people do) and you have the perfect storm for joint problems.

NIE: What are the top one to two reasons people seek out natural remedies instead of OTC (over-the-counter) products? Lack of side effects? Cheaper? Prefer natural options?

Roza: Our nation has been under attack from the opioid crisis, and when looking at NSAIDs, the side effects such as indigestion, stomach ulcers and allergic reactions are all factors as to why people are seeking natural alternatives—and research is being corroborated that they can be just as effective. A recent study entitled “Herbal formulation ‘turmeric extract, black pepper and ginger’ versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial” in Phytotherapy Research concluded that a botanical formula consisting of turmeric, ginger, and black pepper provided results similar to Naproxen in relieving pain in individuals with osteoarthritis of the knee.

Alimonti: I think we are seeing an increased interest in preventative care through natural solutions and that same interest extends to holistic treatment of existing health issues. Regardless of price, consumers want effective products that don’t cause more problems than they help with.

Shah: The remedies align with the consumers’ values, beliefs and worldviews. Most OTC products treat the symptoms, while natural botanicals correct the root cause. Natural remedies are also free of side effects most of the time (depending on the ingredients used to formulate them). Moreover, their use in some form has been prevalent for a long time. Natural remedies also offer more personal control and autonomy to the consumer.

Shemesh: Natural remedies usually have a high safety profile, posing very low risk of side effects and are consumed to support health rather than cure disease.

McNamara: Natural products are increasingly more widespread in most consumer product markets, and the OTC market is not exempt. U.S. consumers are increasingly and enthusiastically seeking to live less toxic, more natural lives by choosing products that are less “contaminated” and buy clean products wherever they can.

These sentiments are manifested in the growth of BPA-free packaging, paraben- and formaldehyde-free cosmetics, GMO (genetically modified organism)-free organic foods, and now natural OTCs. While natural OTCs can be more expensive than traditional OTC counterparts, consumers are willing to pay more for them, and many are using them in addition to traditional OTCs.

The desire to use “safer” products with fewer side effects is a primary motivation for purchasers of natural OTCs. About 50 percent of the consumers surveyed perceive natural OTCs to be safer than traditional OTCs.

Alkayali: Consumers are wary of pharmaceuticals, especially the potential negative effects of long-term use, and they are increasingly open to science-based ingredients that can help them live healthier and free of pain.

NIE: For natural relief of pain and inflammation, what are some of the most exciting recent advances in extraction, manufacturing and delivery technologies?

McNamara: At Gencor and the relationship with Pharmako, the technology behind LipiSperse has a significant impact on not just bioavailability, but on what delivery forms that can be used. HydroCurc and are superior ingredients compared to similar ingredients that do not use this technology. Affron extraction helps provide a proper balance of the primary bioactive compounds found in saffron. While Affron (a premium saffron ingredient standardized to 3.5 percent Lepticrosalides) is not a joint health ingredient, it is a great example of innovation with extraction and yielding superior benefits in activity and functionality across multiple delivery formats.

Roza: Unfortunately many herbal bioactives are poorly absorbed and are greatly diminished during first-pass metabolism when administered orally. Formulating these bioactives as liposomes, micelles or through the use of nanotechnology can greatly affect how well it will be utilized by the body—and is the basis of much of the botanical innovation underway at Layn Natural Ingredients. Affecting gene expression through epigenetics also holds a lot of promise as we are gaining a better understanding on how certain bioactives can switch on or turn off a gene to the betterment of the host.

Lelah: Some exciting advances are those that increase the water solubility of an ingredient. The solubility of an ingredient often affects the bioavailability of the active in it, so increased solubility is a promising option for active ingredients that have been traditionally low in activity. Novel extraction, manufacturing and delivery technologies can each contribute to increased solubility in different ways. Enhanced solubility not only provides greater effect, but also faster effects—and that’s what consumers want when it comes to acute pain.

NIE: Based on the science, what are some of the most interesting botanicals, nutrients or compounds for natural inflammation relief?

Kothari: An emerging new class of phytonutrients called iminosugars. Nearly 200 iminosugars, including many with potential medicinal uses, have been discovered in recent decades. Iminosugars are a type of sugar where a nitrogen atom has replaced the oxygen atom in the ring of the structure. This small change can disrupt or restore certain cellular functions, giving iminosugars multiple medicinal properties, which include helping the body reduce inflammation. Peer-reviewed clinical research shows that a specific iminosugar, ido-BR1, is more effective than glucosamine-chondroitin for soothing joint discomfort and increasing flexibility and function.

Another relatively new ingredient is a patented extract from African spice fruit (Dichrostachys glomerate) that is rich in bioactive polyphenols with strong antioxidant and anti-inflammatory properties. Multiple clinical studies show this patented extract can modulate key hormones that govern appetite and insulin sensitivity to help restore metabolic balance and healthy body weight and composition. McNamara: Supported by a wealth of traditional and scientific research, curcuminoids are shown to be amongst some of the most potent antioxidants in the natural world. Benefits have been shown to deliver protective effects against many conditions associated with high levels of inflammation and oxidative stress.

Standard curcuminoid extracts are poorly absorbed by the body, and hence rapidly eliminated. Increasing absorption is key to unlocking the myriad of benefits curcumin has to offer. HydroCurc utilizes Pharmako Biotechnologies’ patented technology LipiSperse, which allows curcuminoids’ normally limited ability to dissolve in aqueous environments like the stomach to be enhanced. Curcuminoid particles are able to freely disperse, increasing bioavailability as it becomes more readily available to the body. HydroCurc delivers curcuminoids to the body faster and more efficiently than standard curcumin extracts.

Superior water dispersion allows HydroCurc to deliver curcuminoids faster than standard curcumin extracts to the body while reaching the highest levels of bioavailability on the market today.

Alkayali: In terms of joint health, collagen continues to expand the boundaries of natural solutions that can help preserve connective tissues and cartilage that help us stay strong, mobile and pain-free. We’re learning more about the collagen types that best stimulate fibroblasts and chondrocytes to produce new collagen to repair damage and maintain extra cellular matrix in joints and lubricate joints with synovial fluid. There is also new research showing the molecular weight required for collagen absorption and optimization by the body.

NIE: For manufacturers, please briefly discuss your top one to two flagship ingredients or finished product formulas for natural pain relief or relief of inflammation.

Hammond: As a bioavailable source of sulfur, OptiMSM, Bergstrom Nutrition’s branded form of methylsulfonylmethane (MSM), helps deter the accumulation of oxidative damage. MSM’s ability to reduce oxidative stress, down-regulate the expression of inflammatory markers, and mitigate inflammation caused by exercise, supports its inclusion in overall wellness, healthy-aging, and joint health applications.

OptiMSM can provide our bodies with healthy levels of sulfur-containing MSM. As people age, it is well-known that chronic systemic inflammation is common and linked to many health concerns, diseases and symptoms, especially for older adults. Multiple studies have shown that MSM reduces oxidative stress, thereby helping protect the body from advanced aging and other detrimental effects of such stress and inflammation. In addition, sulfur in MSM aids in the regeneration of damaged tissues, leading to a faster recovery time—thus improving a person’s overall well-being, allowing them to continue living a healthy and active lifestyle.

Extensive research also demonstrates that OptiMSM decreases joint pain, improves stiffness and swelling, and increases the range-of-motion and physical function. OptiMSM’s mechanism stems from its ability to decrease pro-inflammatory cytokines and reduce oxidative damage by supplying the body a rich source of sulfur.

Alimonti: Curcumin is well known for its anti-inflammatory properties and the micronized technology of MicroActive Curcumin provides 10 times greater absorption than regular curcumin with an extended-release time for longer efficacy.

The patented manufacturing process behind our healthy joint ingredient, AppleActiv DAPP, preserves the polyphenols as well as phytonutrients, which translates to powerful antioxidant activity for anti-inflammatory support. A human clinical study demonstrated supplementation led to improvements in range of motion and joint comfort.

Our ingredient Juvecol—responsibly upcycled from proteoglycans extracted from the cartilage of salmon—is the first naturally produced proteoglycan that is commercially available with clinical substantiation for joint health. Juvecol works by enriching cartilage cells which help repair deteriorated joints to support mobility, flexibility and comfort.

Kothari: IminoTech, Inc. is the manufacturer of Q-actin, an ido-BR1 iminosugar that modulates certain cellular functions to significantly help reduce joint discomfort and improve movement and function. Ex vivo research shows this natural and patented cucumber extract works through several complementary mechanisms.

Gateway Health Alliances is the manufacturer of several ingredients for weight management and metabolic wellness, which also have implications for reducing pain and inflammation, including Dylomera, which is a patented extract from African spice fruit (Dichrostachys glomerate) as known as “Nah Po,” which has a long history in traditional medicine.

As metabolic balance improved with 400 mg of this extract dally, subjects experienced significant reductions in blood markers associated with systemic inflammation, including PAI-1 and C-reactive protein.

Lelah: MorActive is a new, patented extract from the moringa seed, Moringa oleifera. The seeds contain high levels of glucomoringin: these sulfur-containing compounds possess anti-inflammatory and antioxidant properties. MorActive is standardized to >20 percent glucomoringin. In the body, glucomoringin is converted to moringin in the body; moringin has been shown to be a very effective and potent agonist of TRPA1 – this ion channel is a known sensor for pain. By activating TRPA1, moringin desensitizes the ion channel to further stimuli, thus reducing the sensation of pain from these receptors.

SunActive IsoQ is a solubilized, highly bioavailable form of quercetin. Quercetin has been long used for pain; however, in the past it has been poorly soluble and has had extremely low bioavailability. Enhancing the bioavailability by 25 times dramatically increases its potential as a pain remedy.

Alkayali: Clinical research shows that TendoGuard significantly improved the range of motion, general pain and muscle strength of 78 percent subjects who consumed 750 mgs daily for 60 days. The observational study was conducted to evaluate the efficacy of TendoGuard in older adults experiencing joint discomfort and diminished mobility.

TendoGuard is a blend of avian sternum and eggshell membrane that delivers the collagen types (I, II, V and X) essential for maximizing bone, cartilage and tissue repair. Combining collagen types and sources creates collagen peptides optimized maintenance and restoration of articular cartilage, tendons and ligaments.

TendoGuard is carefully hydrolyzed for human absorption while preserving the nutrients and naturally occurring mucopolysaccharides, specifically hyaluronic acid, chondroitin and glucosamine, that support joint health and flexibility.

Another Certified Nutraceuticals collagen product shown to reduce pain and inflammation is KollaGen I.V.X. HEM. This unique combination of collagen types I, V and X extracted from eggshell membrane supports bone, skin and connective tissues. Our hydrolyzation technology enables the extraction and purification of these collagens without harsh chemicals while preserving natural mucopolysaccharides, including hyaluronic acid, glucosamine and chondroitin.

Shemesh: Astaxanthin is one of nature’s most potent antioxidants. Its antioxidant activity contributes to balance the inflammatory response. Astaxanthin was shown to have anti-inflammatory effects in various in vivo and in vitro studies both on acute and chronic inflammatory conditions. The anti-inflammation mechanisms of astaxanthin involves the regulation of genes of inflammatory biomarkers and multiple signaling molecules.

β-glucan polysaccharides are among nature’s immune modulators, helping to prime immune cells, supporting and balancing optimal natural immunity. They help the immune system to respond efficiently to attacks from pathogens.

Beta glucans have been shown in several studies to balance the immune system and help reduce joint and skin inflammation in animal autoimmune disease models.

Roza: I would point to Bio+Quercitrin, a highly bioavailable form for quercetin derived from Sophora japonica, or Japanese pagoda tree. Bio+Quercitrin is a potent, natural antioxidant flavonoid that scavenges free radicals to inhibit oxidative damage, providing up to six times the bioavailability of regular quercetin. When oxidative stress goes unmanaged, inflammation is a potential result, and Layn Natural Ingredients Bio+Quercitrin is a terrific, potent ingredient for use in dietary supplements to provide healthy inflammation response and support.

I would also draw attention to SophorOx, a scientifically supported in-vivo and in-vitro to inhibit pro-inflammatory compounds and reactive molecules that cause oxidative stress. This potent natural antioxidant has been shown to inhibit oxidative stress and support healthy inflammation response. SophorOx is derived from Sophora japonica and contains potent flavonoid actives including quercetin, rutin, isorhamnetin kaempferol, genistin and genistein.

Shah: I would point to TurmXTRA60N: Nutriventia’s low-dose, bioavailable turmeric extract. Turmeric is a natural anti-inflammatory herb known to suppress molecules that play a crucial role in inflammation. I would also mention bsRx25n. bsRx25n is a water-dispersible Boswellia serrata extract targeted for gut health. Boswellia is a time-honored ayurvedic remedy for relieving inflammatory conditions.

NIE: With so much discomfort going around, is it frustrating that structure-function claims and packaging/marketing language for these health areas needs to be so incredibly wishy-washy/circumspect?

McNamara: This is beyond frustrating. The inability to make claims for decreasing inflammation is like having your hands tied and duct tape across your mouth. The consumer understands that inflammation is most likely the root cause of their discomfort. This makes it very challenging to convey a marketing message. Companies are getting creative with images though or with the branding (name) of their products and ingredients.

Kothari: It is difficult to discuss peer-reviewed clinical studies related to pain or inflammation without having it be misconstrued as a disease claim. IminoTech’s Q-actin, for example, works to reduced pro-inflammatory cytokine responses. To avoid running afoul of FDA (U.S. Food and Drug Administration) guidelines, simply positioning our products for healthy joint support does not distinguish them from other products.

Lelah: The problem is that the FDA will only allow such claims as relief from acute muscle pain due to exercise. However, this doesn’t tell the whole story about pain for headaches, backache, joint pain, etc. So, the industry is left with being wishy/washy and circumspect, hoping that consumers will understand that these natural remedies are also effective for other kinds of pain.

Alimonti: It is unfortunate that side-effect-laden OTC remedies can make blatant pain relief and inflammation-relief claims. However, Maypro remains focused on developing a portfolio of proprietary branded ingredients with published human clinical research. Market trends are showing that brand manufacturers are focused on developing science-backed high-quality finished products. We think this is rooted in increasing consumer demand for effective holistic solutions.

Shah: The structure-function claims most definitely need to be carefully worded to ensure that they are not misinterpreted. As a policy, all our claims are backed by relevant clinical studies, which makes it easier for us to be straightforward with the claims made by our branded ingredients.

We also work with reputed law firms based out of the United States who vet our trials with appropriate claims. These are FDA-notified and serve as an additional check for our customers.

Roza: Most definitely. Wordsmithing the attributes of botanicals to convey their intrinsic value can be quite challenging to not run afoul of the FDA since any reference to alleviating pain and managing joint disfunction or other maladies are considered drug claims.

Alkayali: It’s important that product formulators focus on science-based ingredients that demonstrate joint health benefits in clinical studies. Products that maintain or increase joint strength, motion and flexibility will have implied comfort benefits. Many consumers will understand that significant improvements in joint functionality is not possible without relief from pain and inflammation. And for consumers who read labels and research, there is a strong scientific link between the mechanism of collagen peptides supplementation and improvements in joint health that strengthens the reasons to believe.

Meppem: Regulatory restrictions are always frustrating, yet many of Pharmako’s clients find ways to position products through interesting marketing and informative education pieces.

In many markets the repeat sales due to efficacious formulations is assisting in spreading the word among consumers. The power of “earned” recommendations is sometimes underestimated.

Pharmako’s trademarked technologies and ingredients are becoming well known, as their scientific and clinical studies validate their effectiveness, which leads to trade marketing and award recognition. Our ingredient and corporate websites receive lots of international traffic and enquiries about where ingredients, such as HydroCurc, are available.

NIE: What would you like to add?

McNamara: Not all PEA is created equal. Due to PEA’s lipophilic nature, it comes across many challenges—both from a bioavailability and formulation perspective as the PEA particles clump up together and have limited absorption and versatility. For that reason, delivery technologies can be applied to PEA to overcome such challenges and deliver highly bioavailable forms of PEA in unique formats.

LipiSperse is an advanced cold water dispersion technology (CWD). Allowing solid/powder lipophilic active ingredients such as palmitoylethanolamide (PEA), with otherwise relatively low bioavailability and poor solubility in water, to be easily dispersed in cold water, thereby increasing their bioavailability and uptake in the body. Superior performance means only 10 percent LipiSperse is required with an impressive 90 percent active load, the largest active/nutrient ratio in a water-soluble formulation.

Shah: Consumers today are more educated than ever, and the world is moving towards natural alternatives. As the global anti-inflammatory market grows at a CAGR of 4 percent, I only see more opportunities for ingredient manufacturers and finished formulators. The future for this particular market looks exciting, and we at Nutriventia can’t wait to innovate and experiment with more botanicals and technology platforms!

Lelah: The challenge for natural pain remedies is that they mostly are not fast-acting. Unlike drugs which can target nerves and nerve processes, natural products are milder and slower in effect. Consumers want immediate relief. This is the pot at the end of the natural rainbow. NIE

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